RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
miR-877-3p
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
qRT-PCR; Dual-luciferase reporter assay; Immunofluorescence etc.
Target
Smad7
Pathway
NA
PubMed ID
Title
MiR-877-3p targets Smad7 and is associated with myofibroblast differentiation and bleomycin-induced lung fibrosis
Year
2016
Function
"MiR-877-3p is highly up-regulated in the myofibroblast differentiation of LR-MSCs and in the fibrotic lung. More importantly, we found that miR-877-3p sequestration inhibited the myofibroblast differentiation of LR-MSCs and attenuates bleomycin-induced lung fibrosis by targeting Smad7."